Inhibition of Gap Junctions Sensitizes Primary Glioblastoma Cells for Temozolomide.

ABSTRACT: Gap junctions have recently been shown to interconnect glioblastoma cells to a multicellular syncytial network, thereby allowing intercellular communication over long distances as well as enabling glioblastoma cells to form routes for brain microinvasion. Against this backdrop gap junction-targeted therapies might provide for an essential contribution to isolate cancer cells within the brain, thus increasing the tumor cells' vulnerability to the standard chemotherapeutic agent temozolomide. By utilizing INI-0602-a novel gap junction inhibitor optimized for crossing the blood brain barrier-in an oncological setting, the present study was aimed at evaluating the potential of gap junction-targeted therapy on primary human glioblastoma cell populations. Pharmacological inhibition of gap juncti

SUBMITTER: Potthoff AL 

PROVIDER: S-EPMC6628126 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature