Penetration and Accumulation of Dendrons with Different Peripheral Composition in Pseudomonas aeruginosa Biofilms.

ABSTRACT: Multidrug resistant bacterial infections threaten to become the number one cause of death by the year 2050. Development of antimicrobial dendritic polymers is considered promising as an alternative infection control strategy. For antimicrobial dendritic polymers to effectively kill bacteria residing in infectious biofilms, they have to penetrate and accumulate deep into biofilms. Biofilms are often recalcitrant to antimicrobial penetration and accumulation. Therefore, this work aims to determine the role of compact dendrons with different peripheral composition in their penetration into Pseudomonas aeruginosa biofilms. Red fluorescently labeled dendrons with pH-responsive NH₃⁺ peripheral groups initially penetrated faster from a buffer suspension at pH 7.0 into

SUBMITTER: Rozenbaum RT 

PROVIDER: S-EPMC6628176 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature