Association of infections and venous thromboembolism in hospitalized children with nephrotic syndrome.

ABSTRACT:

Background

Nephrotic syndrome (NS) results in hypercoagulability and increased risk of infection. Furthermore, infection increases the risk of venous thromboembolism (VTE). Our objective was to determine the prevalence of infection, VTE, and the associated outcomes among a cohort of hospitalized children with NS.

Methods

All children with NS admitted to 17 pediatric hospitals across North America from 2010 to 2012 were included. Prevalence of infection and VTE was determined. Wilcoxon rank-sum and logistic regression were performed.

Results

Seven-hundred thirty hospitalizations occurred among 370 children with NS. One-hundred forty-eight children (40%) had ≥ 1 infection (211 episodes) and 11 (3%) had VTE. Those with VTE had infection more frequently (p = 0.046) and we

SUBMITTER: Carpenter SL 

PROVIDER: S-EPMC6628263 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature