Allergies and Childhood Acute Lymphoblastic Leukemia: A Case-Control Study and Meta-analysis.

ABSTRACT: Background: Allergic disease is suspected to play a role in the development of childhood acute lymphoblastic leukemia (ALL). Studies conducted over the last several decades have yielded mixed results.Methods: We examined the association between allergy, a common immune-mediated disorder, and ALL in the California Childhood Leukemia Study (CCLS), a case-control study of 977 children diagnosed with ALL and 1,037 matched controls (1995-2015). History of allergies in the first year of life was obtained from interviews, mainly reported by mothers. Logistic regression analyses were conducted to estimate ORs and 95% confidence intervals (CIs), controlling for birth order, daycare attendance, and mode of delivery. In addition, we conducted meta-analyses with data from the CCLS and 12

SUBMITTER: Wallace AD 

PROVIDER: S-EPMC6628274 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature