Circulating miRNAs in Untreated Breast Cancer: An Exploratory Multimodality Morpho-Functional Study.

ABSTRACT: The aim of this study was to identify new disease-related circulating miRNAs with high diagnostic accuracy for breast cancer (BC) and to correlate their deregulation with the morpho-functional characteristics of the tumour, as assessed in vivo by positron emission tomography/magnetic resonance (PET/MR) imaging. A total of 77 untreated female BC patients underwent same-day PET/MR and blood collection, and 78 healthy donors were recruited as negative controls. The expression profile of 84 human miRNAs was screened by using miRNA PCR arrays and validated by real-time PCR. The validated miRNAs were correlated with the quantitative imaging parameters extracted from the primary BC samples. Circulating miR-125b-5p and miR-143-3p were upregulated in BC plasma and able to discriminate BC patients f

SUBMITTER: Incoronato M 

PROVIDER: S-EPMC6628327 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature