Radiogenomics of breast cancer using dynamic contrast enhanced MRI and gene expression profiling.

ABSTRACT:

Background

Imaging techniques can provide information about the tumor non-invasively and have been shown to provide information about the underlying genetic makeup. Correlating image-based phenotypes (radiomics) with genomic analyses is an emerging area of research commonly referred to as "radiogenomics" or "imaging-genomics". The purpose of this study was to assess the potential for using an automated, quantitative radiomics platform on magnetic resonance (MR) breast imaging for inferring underlying activity of clinically relevant gene pathways derived from RNA sequencing of invasive breast cancers prior to therapy.

Methods

We performed quantitative radiomic analysis on 47 invasive breast cancers based on dynamic contrast enhanced 3 Tesla MR images acquired before surgery a

SUBMITTER: Yeh AC 

PROVIDER: S-EPMC6628478 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature