Cognitive and Motor Outcomes of Children With Prenatal Opioid Exposure: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

Prenatal opioid exposure (POE) is one of the fastest-growing global health problems, but its association with long-term neurologic and physical development remains unknown.

Objective

To assess the association between POE and cognitive and motor development in children from age 6 months to 18 years.

Data sources

Key search terms included prenatal opioid exposure, neonatal abstinence syndrome, and neurocognitive development. Studies were searched using PubMed and Embase, with no publication date restriction, through August 20, 2018.

Study selection

Only published cohort studies comparing the results of age-appropriate standardized cognitive and/or motor tests between children with any POE (aged 0-18 years) with drug-free controls were included. Data th

SUBMITTER: Yeoh SL 

PROVIDER: S-EPMC6628595 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature