Association of Lifespan Cognitive Reserve Indicator With Dementia Risk in the Presence of Brain Pathologies.

ABSTRACT:

Importance

Evidence on the association of lifespan cognitive reserve (CR) with dementia is limited, and the strength of this association in the presence of brain pathologies is unknown.

Objective

To examine the association of lifespan CR with dementia risk, taking brain pathologies into account.

Design, setting, and participants

This study used data from 2022 participants in the Rush Memory and Aging Project, an ongoing community-based cohort study with annual follow-up from 1997 to 2018 (mean follow-up, 6 years; maximum follow-up, 20 years). After excluding 420 individuals who had prevalent dementia, missing data on CR, or dropped out, 1602 dementia-free adults were identified at baseline and evaluated to detect incident dementia. During follow-up, 611 died and under

SUBMITTER: Xu H 

PROVIDER: S-EPMC6628596 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature