Dynamic secretome of bone marrow-derived stromal cells reveals a cardioprotective biochemical cocktail.

ABSTRACT: Transplanted stromal cells have demonstrated considerable promise as therapeutic agents in diverse disease settings. Paracrine signaling can be an important mediator of these therapeutic effects at the sites of acute or persistent injury and inflammation. As many stromal cell types, including bone marrow-derived stromal cells (BMSCs), display tissue-specific responses, there is a need to explore their secretory dynamics in the context of tissue and injury type. Paracrine signals are not static, and could encode contextual dynamics in the kinetic changes of the concentrations of the secreted ligands. However, precise measurement of dynamic and context-specific cellular secretory signatures, particularly in adherent cells, remains challenging. Here, by creating an experimental and computatio

SUBMITTER: Kshitiz 

PROVIDER: S-EPMC6628676 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature