Ontology highlight
ABSTRACT:
SUBMITTER: Hasan N
PROVIDER: S-EPMC6628893 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Cell reports 20190601 11
Throughout the CNS, interactions between pre- and postsynaptic adhesion molecules establish normal synaptic structure and function. Leucine-rich repeat (LRR) domain-containing proteins are a large family that has a diversity of ligands, and their absence can cause disease. At the first retinal synapse, the absence of LRIT3 expression leads to the disassembly of the postsynaptic glutamate signaling complex (signalplex) expressed on depolarizing bipolar cell (DBC) dendrites. The prevalent view is ...[more]