Time-Dependent Molecular Responses Differ between Gastric Bypass and Dieting but Are Conserved Across Species.

ABSTRACT: The effectiveness of Roux-en-Y gastric bypass (RYGB) against obesity and its comorbidities has generated excitement about developing new, less invasive treatments that use the same molecular mechanisms. Although controversial, RYGB-induced improvement of metabolic function may not depend entirely upon weight loss. To elucidate the differences between RYGB and dieting, we studied several individual organ molecular responses and generated an integrative, interorgan view of organismal physiology. We also compared murine and human molecular signatures. We show that, although dieting and RYGB can bring about the same degree of weight loss, post-RYGB physiology is very different. RYGB induces distinct, organ-specific adaptations in a temporal pattern that is characterized by energetically demand

SUBMITTER: Ben-Zvi D 

PROVIDER: S-EPMC6628900 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature