Reduction of repetitive behavior by co-administration of adenosine receptor agonists in C58 mice.

ABSTRACT: Repetitive behaviors are diagnostic for autism spectrum disorder (ASD) and commonly observed in other neurodevelopmental disorders. Currently, there are no effective pharmacological treatments for repetitive behavior in these clinical conditions. This is due to the lack of information about the specific neural circuitry that mediates the development and expression of repetitive behavior. Our previous work in mouse models has linked repetitive behavior to decreased activation of the subthalamic nucleus, a brain region in the indirect and hyperdirect pathways in the basal ganglia circuitry. The present experiments were designed to further test our hypothesis that pharmacological activation of the indirect pathway would reduce repetitive behavior. We used a combination of adenosine A1 and A2A

SUBMITTER: Lewis MH 

PROVIDER: S-EPMC6629027 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature