Identification of dicarbonyl and L-xylulose reductase as a therapeutic target in human chronic kidney disease.

ABSTRACT: An imbalance of nephroprotective factors and renal damaging molecules contributes to development and progression of chronic kidney disease (CKD). We investigated associations of renoprotective factor gene expression patterns with CKD severity and outcome. Gene expression profiles of 197 previously reported renoprotective factors were analyzed in a discovery cohort in renal biopsies of 63 CKD patients. Downregulation of dicarbonyl and L-xylulose reductase (DCXR) showed the strongest association with disease progression. This significant association was validated in an independent set of 225 patients with nephrotic syndrome from the multicenter NEPTUNE cohort. Reduced expression of DCXR was significantly associated with degree of histological damage as well as with lower estimated glomerular

SUBMITTER: Perco P 

PROVIDER: S-EPMC6629103 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature