Cannabinoid receptor 2 deficiency exacerbates inflammation and neutrophil recruitment.

ABSTRACT: Cannabinoid receptor (CB)₂ is an immune cell-localized GPCR that has been hypothesized to regulate the magnitude of inflammatory responses. However, there is currently no consensus as to the mechanism by which CB₂ mediates its anti-inflammatory effects in vivo. To address this question, we employed a murine dorsal air pouch model with wild-type and CB₂^-/- 8-12-wk-old female and male C57BL/6 mice and found that acute neutrophil and lymphocyte antigen 6 complex, locus C^hi monocyte recruitment in response to Zymosan was significantly enhanced in CB₂^-/- mice. Additionally, levels of matrix metalloproteinase 9 and the chemokines C-C motif chemokine ligand (CCL)2, CCL4, and C-X-C motif chemokine ligand 10 in CB

SUBMITTER: Kapellos TS 

PROVIDER: S-EPMC6629158 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature