Recalibration of path integration in hippocampal place cells.

ABSTRACT: Hippocampal place cells are spatially tuned neurons that serve as elements of a 'cognitive map' in the mammalian brain¹. To detect the animal's location, place cells are thought to rely upon two interacting mechanisms: sensing the position of the animal relative to familiar landmarks^2,3 and measuring the distance and direction that the animal has travelled from previously occupied locations^4-7. The latter mechanism-known as path integration-requires a finely tuned gain factor that relates the animal's self-movement to the updating of position on the internal cognitive map, as well as external landmarks to correct the positional error that accumulates^8,9. Models of hippocampal place cells and entorhinal grid cells based on path integration treat t

SUBMITTER: Jayakumar RP 

PROVIDER: S-EPMC6629428 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature