Development of hypotension in patients newly diagnosed with heart failure in UK general practice: retrospective cohort and nested case-control analyses.

ABSTRACT:

Objectives

Hypotension is of particular relevance for patients with heart failure (HF), since almost all HF drugs cause lowering of blood pressure (BP) and it is associated with a poor prognosis. We aimed to investigate hypotension incidence and risk factors in patients with incident HF in the UK.

Design

Retrospective cohort study including nested case-control analyses.

Setting

The Health Improvement Network UK primary care database.

Participants

18 677 adult patients with incident HF during 2000-2005 were followed and cases of hypotension (systolic BP ≤90 mm Hg) were identified. Controls were age-matched, sex-matched and date-matched to cases (1:2).

Primary and secondary outcome measures

We estimated hypotension incidence in the full study population an

SUBMITTER: Martin-Perez M 

PROVIDER: S-EPMC6629451 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature