Tenofovir concentrations in hair strongly predict virologic suppression in breastfeeding women.

ABSTRACT:

Background

Antiretroviral treatment (ART) adherence is often suboptimal in the perinatal period. We measured hair tenofovir (TFV) concentrations as a metric of adherence in postpartum women to understand patterns and predictors of adherence throughout this critical period. In addition, we examined the association between hair TFV concentrations and virologic outcomes.

Methods

Between 12/2012 and 09/2016, hair samples were collected longitudinally from delivery through breastfeeding from women on ART in the Promoting Maternal and Infant Survival Everywhere study (NCT01061151) in sub-Saharan Africa. Hair TFV levels were measured using validated methods. Using generalized estimating equations, we estimated the association between hair TFV levels and virologic suppression (<400

SUBMITTER: Murnane PM 

PROVIDER: S-EPMC6629471 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature