Structural MRI at 7T reveals amygdala nuclei and hippocampal subfield volumetric association with Major Depressive Disorder symptom severity.

ABSTRACT: Subcortical volumetric changes in major depressive disorder (MDD) have been purported to underlie depressive symptomology, however, the evidence to date remains inconsistent. Here, we investigated limbic volumes in MDD, utilizing high-resolution structural images to allow segmentation of the hippocampus and amygdala into their constituent substructures. Twenty-four MDD patients and twenty matched controls underwent structural MRI at 7T field strength. All participants completed the Montgomery-Asberg Depression Rating Scale (MADRS) to quantify depressive symptomology. For the MDD group, volumes of the amygdala right lateral nucleus (p = 0.05, r² = 0.24), left cortical nucleus (p = 0.032, r² = 0.35), left accessory basal nucleus (p = 0.04, r² = 0.28) and bila

SUBMITTER: Brown SSG 

PROVIDER: S-EPMC6629636 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature