Detection of cell-type-specific risk-CpG sites in epigenome-wide association studies.

ABSTRACT: In epigenome-wide association studies, the measured signals for each sample are a mixture of methylation profiles from different cell types. Current approaches to the association detection claim whether a cytosine-phosphate-guanine (CpG) site is associated with the phenotype or not at aggregate level and can suffer from low statistical power. Here, we propose a statistical method, HIgh REsolution (HIRE), which not only improves the power of association detection at aggregate level as compared to the existing methods but also enables the detection of risk-CpG sites for individual cell types.

SUBMITTER: Luo X 

PROVIDER: S-EPMC6629651 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature