Perturbation of ubiquitin homeostasis promotes macrophage oxidative defenses.

ABSTRACT: The innate immune system senses microbial ligands through pattern recognition and triggers downstream signaling cascades to promote inflammation and immune defense mechanisms. Emerging evidence suggests that cells also recognize alterations in host processes induced by infection as triggers. Protein ubiquitination and deubiquitination are post-translational modification processes essential for signaling and maintenance of cellular homeostasis, and infections can cause global alterations in the host ubiquitin proteome. Here we used a chemical biology approach to perturb the cellular ubiquitin proteome as a simplified model to study the impact of ubiquitin homeostasis alteration on macrophage function. Perturbation of ubiquitin homeostasis led to a rapid and transient burst of reactive oxyge

SUBMITTER: Charbonneau ME 

PROVIDER: S-EPMC6629656 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature