Radionuclide generator-based production of therapeutic ¹⁷⁷Lu from its long-lived isomer ^177mLu.

ABSTRACT:

Background

In this work, a lutetium-177 (¹⁷⁷Lu) production method based on the separation of nuclear isomers, ^177mLu & ¹⁷⁷Lu, is reported. The ^177mLu-¹⁷⁷Lu separation is performed by combining the use of DOTA & DOTA-labelled peptide (DOTATATE) and liquid-liquid extraction.

Methods

The ^177mLu cations were complexed with DOTA & DOTATATE and kept at 77 K for periods of time to allow ¹⁷⁷Lu production. The freed ¹⁷⁷Lu ions produced via internal conversion of ^177mLu were then extracted in dihexyl ether using 0.01 M di-(2-ethylhexyl) phosphoric acid (DEHPA) at room temperature. The liquid-liquid extractions were performed periodically for a period up to 35 days.

Results

A maxim

SUBMITTER: Bhardwaj R 

PROVIDER: S-EPMC6629729 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature