Distinct Conformations, Aggregation and Cellular Internalization of Different Tau Strains.

ABSTRACT: The inter-cellular propagation of tau aggregates in several neurodegenerative diseases involves, in part, recurring cycles of extracellular tau uptake, initiation of endogenous tau aggregation, and extracellular release of at least part of this protein complex. However, human brain tau extracts from diverse tauopathies exhibit variant or "strain" specificity in inducing inter-cellular propagation in both cell and animal models. It is unclear if these distinctive properties are affected by disease-specific differences in aggregated tau conformation and structure. We have used a combined structural and cell biological approach to study if two frontotemporal dementia (FTD)-associated pathologic mutations, V337M and N279K, affect the aggregation, conformation and cellular internalization of th

SUBMITTER: Karikari TK 

PROVIDER: S-EPMC6629824 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature