Enhancement of Cardiac Store Operated Calcium Entry (SOCE) within Novel Intercalated Disk Microdomains in Arrhythmic Disease.

ABSTRACT: Store-operated Ca²⁺ entry (SOCE), a major Ca²⁺ signaling mechanism in non-myocyte cells, has recently emerged as a component of Ca²⁺ signaling in cardiac myocytes. Though it has been reported to play a role in cardiac arrhythmias and to be upregulated in cardiac disease, little is known about the fundamental properties of cardiac SOCE, its structural underpinnings or effector targets. An even greater question is how SOCE interacts with canonical excitation-contraction coupling (ECC). We undertook a multiscale structural and functional investigation of SOCE in cardiac myocytes from healthy mice (wild type; WT) and from a genetic murine model of arrhythmic disease (catecholaminergic ventricular tachycardia; CPVT). Here we provide the first demonstration of lo

SUBMITTER: Bonilla IM 

PROVIDER: S-EPMC6629850 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature