Targeting the Serine Pathway: A Promising Approach against Tuberculosis?

ABSTRACT: Tuberculosis is still the leading cause of death by a single infectious agent. Effective chemotherapy has been used and improved since the 1950s, but strains resistant to this therapy and most antibacterial drugs on the market are emerging. Only 10 new drugs are in clinical trials, and two of them have already demonstrated resistance. This paper gives an overview of current treatment options against tuberculosis and points out a promising approach of discovering new effective drugs. The serine production pathway is composed of three enzymes (SerA1, SerC and SerB2), which are considered essential for bacterial growth, and all of them are considered as a therapeutic drug target. Their crystal structure are described and essential regulatory domains pointed out. Sequence alignment with simila

SUBMITTER: Haufroid M 

PROVIDER: S-EPMC6630544 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature