Low Molecular Weight Gelators Based on Functionalized l-Dopa Promote Organogels Formation.

ABSTRACT: We prepared the small pseudopeptide Lau-l-Dopa(OBn)₂-d-Oxd-OBn (Lau = lauric acid; l-Dopa = l-3,4-dihydroxyphenylalanine; d-Oxd = (4R,5S)-4-methyl-5-carboxyl-oxazolidin-2-one; Bn = benzyl) through a number of coupling reactions between lauric acid, protected l-Dopa and d-Oxd with an excellent overall yield. The ability of the product to form supramolecular organogels has been tested with different organic solvents of increasing polarity and compared with the results obtained with the small pseudopeptide Fmoc-l-Dopa(OBn)₂-d-Oxd-OBn. The mechanical and rheological properties of the organogels demonstrated solvent-dependent properties, with a storage modulus of 82 kPa for the ethanol organogel. Finally, to have a preliminary test of the organogels' ability

SUBMITTER: Giuri D 

PROVIDER: S-EPMC6630615 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature