Antiproliferative Benzoindazolequinones as Potential Cyclooxygenase-2 Inhibitors.

ABSTRACT: Quinones and nitrogen heterocyclic moieties have been recognized as important pharmacophores in the development of antitumor agents. This study aimed to establish whether there was any correlation between the in silico predicted parameters and the in vitro antiproliferative activity of a family of benzoindazolequinones (BIZQs), and to evaluate overexpressed proteins in human cancer cells as potential biomolecular targets of these compounds. For this purpose, this study was carried out using KATO-III and MCF-7 cell lines as in vitro models. Docking results showed that these BIZQs present better binding energies (ΔG_bin) values for cyclooxygenase-2 (COX-2) than for other cancer-related proteins. The predicted ∆G_bin values of these BIZQs, classified in three

SUBMITTER: Molinari A 

PROVIDER: S-EPMC6630654 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature