Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H₂O₂- and Aβ_1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells.

ABSTRACT: With the lack of available drugs able to prevent the progression of Alzheimer's disease (AD), the discovery of new neuroprotective treatments able to rescue neurons from cell injury is presently a matter of extreme importance and urgency. Here, we were inspired by the widely reported potential of natural flavonoids to build a library of novel flavones, chromen-4-ones and their C-glucosyl derivatives, and to explore their ability as neuroprotective agents with suitable pharmacokinetic profiles. All compounds were firstly evaluated in a parallel artificial membrane permeability assay (PAMPA) to assess their effective permeability across biological membranes, namely the blood-brain barrier (BBB). With this test, we aimed not only at assessing if our candidates would be well-distributed

SUBMITTER: de Matos AM 

PROVIDER: S-EPMC6630837 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature