Dynamic Changes of Plasma Metabolome in Response to Severe Feed Restriction in Pregnant Ewes.

ABSTRACT: Maternal metabolic disorders in ewes induced by energy deficiency have a detrimental effect on the maternal health and lambs. However, the dynamic processes of metabolic disorders are unknown. Therefore, this study attempted to explore the dynamic changes of maternal metabolism based on metabolomics approach during energy deficiency in pregnant ewes. Twenty pregnant Hu sheep were fed a basic diet or a 70% restricted basic diet. The HPLC-MS platform was applied to identify blood metabolites. Principal component analysis of blood samples based on their metabolic profile showed that blood samples of feed restriction group differed after the treatment. In particular, when comparing both groups, there were 120, 129, and 114 differential metabolites at day 5, day 10, and day 114 between the two

SUBMITTER: Guo C 

PROVIDER: S-EPMC6630903 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature