Blood Pressure and Cognitive Decline in Prevalent Hemodialysis Patients.

ABSTRACT:

Background

Hypertension is associated with cognitive decline in the general population. It is unclear what impact blood pressure (BP) has on cognitive decline in patients receiving maintenance hemodialysis (HD).

Methods

Using a longitudinal cohort of 314 prevalent HD patients without dementia at baseline, we examined the association of predialysis systolic BP (SBP) and diastolic BP (DBP), pulse pressure, and intradialytic SBP change (pre minus post), averaged for a month, with cognitive decline. Cognitive function was determined by a neurocognitive battery, administered yearly. Individual cognitive test results were reduced into 2 domain scores using principal components analysis (by definition mean of 0 and SD of 1), representing memory and executive function. Joint models,

SUBMITTER: Drew DA 

PROVIDER: S-EPMC6631042 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature