Computational Approaches and Challenges to Developing Universal Influenza Vaccines.

ABSTRACT: The traditional design of effective vaccines for rapidly-evolving pathogens, such as influenza A virus, has failed to provide broad spectrum and long-lasting protection. With low cost whole genome sequencing technology and powerful computing capabilities, novel computational approaches have demonstrated the potential to facilitate the design of a universal influenza vaccine. However, few studies have integrated computational optimization in the design and discovery of new vaccines. Understanding the potential of computational vaccine design is necessary before these approaches can be implemented on a broad scale. This review summarizes some promising computational approaches under current development, including computationally optimized broadly reactive antigens with consensus sequences, p

SUBMITTER: Qiu X 

PROVIDER: S-EPMC6631137 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature