Mechanical Properties of Ca-Saturated Hydrogels with Functionalized Alginate.

ABSTRACT: In this work, the mechanical properties and stability of alginate hydrogels containing functionalized alginates (peptide and β-cyclodextrin) were studied. There is an increasing interest in the modification of alginates to add functions such as cell attachment and increased solubility of hydrophobic drugs, for better performance in tissue engineering and drug release, respectively. Functionalization was achieved in this study via periodate oxidation followed by reductive amination, previously shown to give a high and controllable degree of substitution. Young's modulus and the stress at rupture of the hydrogels were in general lowered when exchanging native alginate with the modified alginate. Still, the gel strength could be adjusted by the fraction of modified alginate in the mixed hydro

SUBMITTER: Dalheim MO 

PROVIDER: S-EPMC6631140 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature