More than a Toxin: Protein Inventory of Clostridium tetani Toxoid Vaccines.

ABSTRACT: Clostridium tetani is the etiological agent of tetanus, a life-threatening bacterial infection. The most efficient protection strategy against tetanus is a vaccination with the C. tetani neurotoxin, which is inactivated by formaldehyde-crosslinking. Since we assumed that besides the tetanus toxin, other proteins of C. tetani may also be present in toxoid preparations, we analyzed commercially available vaccines from different countries in respect to their protein content using mass spectrometry. In total 991 proteins could be identified in all five analyzed vaccines, 206 proteins were common in all analyzed vaccines and 54 proteins from the 206 proteins were potential antigens. The additionally present proteins may contribute at least partially to protection against

SUBMITTER: Moller J 

PROVIDER: S-EPMC6631180 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature