Proband and Familial Autoimmune Diseases Are Associated With Proband Diagnosis of Autism Spectrum Disorders.

ABSTRACT:

Objective

There is evidence that parental autoimmune diseases (ADs) are associated with autism spectrum disorders (ASD) in offspring. The association between offspring ASD and ADs diagnosed in siblings and probands remains less clear. We examined whether proband and familial diagnoses of ADs were associated with increased odds of ASD in probands.

Method

The study is based on a nested case-control design that used data from a large national birth cohort (N = 1.2 million) in Finland. There were 4,600 cases of ASD and controls matched 1:4 on date of birth, sex, and residence. Data were accessed from national medical, birth, and central registries.

Results

Probands had a statistically significant increase in odds of ASD when they (adjusted odds ratio [OR] = 1.2), their mo

SUBMITTER: Spann MN 

PROVIDER: S-EPMC6631342 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature