Postictal ammonia as a biomarker for electrographic convulsive seizures: A prospective study.

ABSTRACT:

Objective

Transient hyperammonemia (THA) was reported to follow generalized convulsions without sufficient evidence to confirm the epileptic nature of those events. We aimed to determine if postictal THA can differentiate between different types of events as confirmed electroencephalographically using video-electroencephalography (vEEG) monitoring.

Methods

In our prospective cohort, we screened all consented adults (>18 years) admitted to the epilepsy monitoring unit. Ammonia was checked at baseline, within 60 min of the event (for all patients) and 24 h after event (whenever possible). Patients were grouped into generalized convulsive seizures (GCS), psychogenic nonepileptic seizures with convulsions (PNES-C), or focal seizures (FS) based on vEEG. Data were analyzed using d

SUBMITTER: Albadareen R 

PROVIDER: S-EPMC6631345 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature