SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis.

ABSTRACT: Atherosclerosis, which underlies life-threatening cardiovascular disorders such as myocardial infarction and stroke¹, is initiated by passage of low-density lipoprotein (LDL) cholesterol into the artery wall and its engulfment by macrophages, which leads to foam cell formation and lesion development^2,3. It is unclear how circulating LDL enters the artery wall to instigate atherosclerosis. Here we show in mice that scavenger receptor class B type 1 (SR-B1) in endothelial cells mediates the delivery of LDL into arteries and its accumulation by artery wall macrophages, thereby promoting atherosclerosis. LDL particles are colocalized with SR-B1 in endothelial cell intracellular vesicles in vivo, and transcytosis of LDL across endothelial monolayers requires its direct bin

SUBMITTER: Huang L 

PROVIDER: S-EPMC6631346 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature