De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria.

ABSTRACT: Antimicrobial peptides (AMPs) have been identified as a potentially new class of antibiotics to combat bacterial resistance to conventional drugs. The design of de novo AMPs with high therapeutic indexes, low cost of synthesis, high resistance to proteases and high bioavailability remains a challenge. Such design requires computational modeling of antimicrobial properties. Currently, most computational methods cannot accurately calculate antimicrobial potency against particular strains of bacterial pathogens. We developed a tool for AMP prediction (Special Prediction (SP) tool) and made it available on our Web site (https://dbaasp.org/prediction). Based on this tool, a simple algorithm for the design of de novo AMPs (DSP) was created. We used DSP to design short peptides with high therapeu

SUBMITTER: Vishnepolsky B 

PROVIDER: S-EPMC6631481 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature