Lipid metabolism impairment in patients with sepsis secondary to hospital acquired pneumonia, a proteomic analysis.

ABSTRACT:

Background

Sepsis is a dysregulated host response to infection and a major cause of death worldwide. Respiratory tract infections account for most sepsis cases and depending on the place of acquisition, i.e., community or hospital acquired infection, differ in etiology, antimicrobial resistance and outcomes. Accordingly, the host response may be different in septic patients secondary to community-acquired pneumonia and hospital acquired pneumonia (HAP). Proteomic analysis is a useful approach to evaluate broad alterations in biological pathways that take place during sepsis. Here we evaluated plasma proteome changes in sepsis secondary to HAP.

Methods

Plasma samples were obtained from patients (n = 27) at admission and after 7 days of follow-up, and were analyzed according t

SUBMITTER: Sharma NK 

PROVIDER: S-EPMC6631513 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature