Metabolomic signatures and microbial community profiling of depressive rat model induced by adrenocorticotrophic hormone.

ABSTRACT:

Background

Adrenocorticotrophic hormone (ACTH)-treatment rat model has been utilized as a widely accepted model of treatment-resistant depression. Metabolomic signatures represent the pathophysiological phenotype of diseases. Recent studies in gut microbiota and metabolomics analysis revealed the dramatic role of microbiome in psychoneurological system diseases, but still, the mechanisms underlying gut microbiome-host interaction remain unclear.

Methods

Male Wistar rats were s.c. injection of ACTH fragment 1-24 for 14 days to induce treatment-resistant depression. Depression-related behavioral tests, analysis of serum monoamine neurotransmitters and hypothalamic-pituitary-adrenal (HPA) axis-related hormones were determined for assessment of ACTH-induced depression rat model.

SUBMITTER: Song J 

PROVIDER: S-EPMC6631535 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature