A Robust Approach for Identification of Cancer Biomarkers and Candidate Drugs.

ABSTRACT: Background and objectives: Identification of cancer biomarkers that are differentially expressed (DE) between two biological conditions is an important task in many microarray studies. There exist several methods in the literature in this regards and most of these methods designed especially for unpaired samples, those are not suitable for paired samples. Furthermore, the traditional methods use p-values or fold change (FC) values to detect the DE genes. However, sometimes, p-value based results do not comply with FC based results due to the smaller pooled variance of gene expressions, which occurs when variance of each individual condition becomes smaller. There are some methods that combine both p-values and FC values to solve this problem. But, those methods

SUBMITTER: Shahjaman M 

PROVIDER: S-EPMC6631768 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature