Impact of inflammation on brain subcellular energetics in anesthetized rats.

ABSTRACT:

Background

Emerging data suggests that volatile anesthetic agents may have organ protection properties in the setting of critical illness. The purpose of this study was to better understand the effect of inflammation on cerebral subcellular energetics in animals exposed to two different anesthetic agents-a GABA agonist (propofol) and a volatile agent (isoflurane).

Results

Forty-eight Sprague-Dawley rats were anesthetized with isoflurane or propofol. In each group, rats were randomized to celiotomy and closure (sham) or cecal ligation and puncture (inflammation [sepsis model]) for 8 h. Brain tissue oxygen saturation and the oxidation state of cytochrome aa₃ were measured. Brain tissue was extracted using the freeze-blow technique. All rats experienced progressive i

SUBMITTER: Thiele RH 

PROVIDER: S-EPMC6631861 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature