Meta-analysis of pain and function placebo responses in pharmacological osteoarthritis trials.

ABSTRACT:

Objective

To evaluate contextual effects in the form of placebo responses (PRs) for patient-reported pain and function and objectively measured function in osteoarthritis (OA) clinical trials.

Methods

Two authors independently searched major electronic databases from inception to 20 May 2019. Included studies were randomized, placebo-controlled OA trials of pharmacological agents reporting both patient-reported and objectively measured outcomes. PRs for each type of outcome measure were compared by standardized mean differences (SMDs). The placebo response ratio (PRR) assessed the placebo to treatment effect size. The effect sizes of PRs and PRRs were pooled using a random effects model.

Results

Twenty-one trials met the inclusion criteria; 20 were double-blinded with

SUBMITTER: Huang Z 

PROVIDER: S-EPMC6631867 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature