Upregulation of cell-surface mucin MUC15 in human nasal epithelial cells upon influenza A virus infection.

ABSTRACT:

Background

Cell-surface mucins are expressed in apical epithelial cells of the respiratory tract, and contribute a crucial part of the innate immune system. Despite anti-inflammatory or antiviral functions being revealed for certain cell-surface mucins such as MUC1, the roles of other mucins are still poorly understood, especially in viral infections.

Methods

To further identify mucins significant in influenza infection, we screened the expression of mucins in human nasal epithelial cells infected by H3N2 influenza A virus.

Results

We found that the expression of MUC15 was significantly upregulated upon infection, and specific only to active infection. While MUC15 did not interact with virus particles or reduce viral replication directly, positive correlations were ob

SUBMITTER: Chen ZG 

PROVIDER: S-EPMC6631914 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature