Development and Validation of an Esophageal Squamous Cell Carcinoma Detection Model by Large-Scale MicroRNA Profiling.

ABSTRACT:

Importance

Patients with late-stage esophageal squamous cell carcinoma (ESCC) have a poor prognosis. Noninvasive screening tests using serum microRNAs (miRNAs) to accurately detect early-stage ESCC are needed to improve mortality.

Objective

To establish a model using serum miRNAs to distinguish patients with ESCC from noncancer controls.

Design, setting, and participants

In this case-control study, serum miRNA expression profiles of patients with ESCC (n = 566) and control patients without cancer (n = 4965) were retrospectively analyzed to establish a diagnostic model, which was tested in a training set and confirmed in a validation set. Patients histologically diagnosed as having ESCC who did not receive prior therapy or have a past or concurrent cancer other than ES

SUBMITTER: Sudo K 

PROVIDER: S-EPMC6632131 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature