An extracellular cation coordination site influences ion conduction of OsHKT2;2.

ABSTRACT:

Background

HKT channels mediate sodium uniport or sodium and potassium symport in plants. Monocotyledons express a higher number of HKT proteins than dicotyledons, and it is only within this clade of HKT channels that cation symport mechanisms are found. The prevailing ion composition in the extracellular medium affects the transport abilities of various HKT channels by changing their selectivity or ion transport rates. How this mutual effect is achieved at the molecular level is still unknown. Here, we built a homology model of the monocotyledonous OsHKT2;2, which shows sodium and potassium symport activity. We performed molecular dynamics simulations in the presence of sodium and potassium ions to investigate the mutual effect of cation species.

Results

By analyzing ion-pr

SUBMITTER: Riedelsberger J 

PROVIDER: S-EPMC6632200 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature