Clinical and microbiologic investigation of an expedited peri-implantitis dog model: an animal study.

ABSTRACT:

Background

Animal studies are pivotal in allowing experimentation to identify efficacious treatment protocols for resolution of peri-implantitis. The purpose of this investigation was to characterize an expedited dog peri-implantitis model clinically, radiographically, and microbiologically.

Methods

Eight hound dogs underwent extractions (week 0) and implant (3.3 × 8.5 mm) placement with simultaneous surgical defect creation and ligature placement for induction of peri-implantitis (week 10). Ligatures were replaced at 6 weeks (week 16) and removed after 9 weeks (week 19) when supporting bone loss involved approximately 50% of the peri-implant bone. Microbial samples from the defects and healthy control implant sites collected at week 19 were analyzed utilizing a microarray.

SUBMITTER: Seong WJ 

PROVIDER: S-EPMC6632201 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature