Second-line antiretroviral therapy regimen change among adults living with HIV in Amhara region: a multi-centered retrospective follow-up study.

ABSTRACT:

Objective

This study was conducted to determine the rate of initial second-line ART regimen change and its predictors among adults living with HIV in Amhara region. A retrospective follow-up study was conducted between February, 2008 and April, 2016 at eight governmental hospitals of Amhara region. Person-times and Cox proportional hazard model were fitted to determine the rate and to identify the significant predictors of second-line treatment regimen change.

Results

A total of 897 records of patients were analyzed. The overall rate of initial second-line drug regimen change was 24.2 per 100 person years. The rate of regimen change was decreased for patients with formal education (HR: 0.77, 95% CI 0.61-0.97), under WHO clinical stage-III (HR: 0.57, 95% CI 0.45-0.73), and WH

SUBMITTER: Alene M 

PROVIDER: S-EPMC6632209 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature