Prognostic implications of statin intolerance in stable coronary artery disease patients with different levels of high-sensitive troponin.

ABSTRACT:

Background

The prognostic implication of statin in tolerance (SI) in those with stable CAD remains unclear. We hypothesized that SI is of higher prognostic significance in stable CAD patients with elevated high-sensitive cardiac troponin I (hs-cTnI).

Methods

A total of 952 stable CAD patients from the prospective Hong Kong CAD study who had complete clinical data, biomarker measurements and who were prescribed statin therapy were studied.

Results

We identified 13 (1.4%) and 125 (13.1%) patients with complete and partial SI, respectively. At baseline, patients with SI were more likely to have diabetes mellitus and a higher hs-cTnI level, but no difference in LDL-C level compared with those without SI. After 51 months of follow-up, patients with SI had a higher mean LDL

SUBMITTER: Hai JJ 

PROVIDER: S-EPMC6633694 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature