Downregulation of CENPF Remodels Prostate Cancer Cells and Alters Cellular Metabolism.

ABSTRACT: Metabolic alterations in prostate cancer (PC) are associated with progression and aggressiveness. However, the underlying mechanisms behind PC metabolic functions are unknown. The authors' group recently reported on the important role of centromere protein F (CENPF), a protein associated with the centromere-kinetochore complex and chromosomal segregation during mitosis, in PC MRI visibility. This study focuses on discerning the role of CENPF in metabolic perturbation in human PC3 cells. A series of bioinformatics analyses shows that CENPF is one gene that is strongly associated with aggressive PC and that its expression is positively correlated with metastasis. By identifying and reconstructing the CENPF network, additional associations with lipid regulation are found. Further untargeted m

SUBMITTER: Shahid M 

PROVIDER: S-EPMC6633900 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature