Longitudinal changes in brain function associated with symptom improvement in youth with PTSD.

ABSTRACT:

Background

Previous studies indicate that youth with posttraumatic stress disorder (PTSD) have abnormal activation in brain regions important for emotion processing. It is unknown whether symptom improvement is accompanied by normative changes in these regions. This study identified neural changes associated with symptom improvement with the long-term goal of identifying malleable targets for interventions.

Methods

A total of 80 functional magnetic resonance imaging (fMRI) scans were collected, including 20 adolescents with PTSD (ages 9-17) and 20 age- and sex-matched healthy control subjects, each scanned before and after a 5-month period. Trauma-focused cognitive behavioral therapy was provided to the PTSD group to ensure improvement in symptoms. Whole brain voxel-wise act

SUBMITTER: Garrett A 

PROVIDER: S-EPMC6633919 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature