Subtypes in patients with opioid misuse: A prognostic enrichment strategy using electronic health record data in hospitalized patients.

ABSTRACT:

Background

Approaches are needed to better delineate the continuum of opioid misuse that occurs in hospitalized patients. A prognostic enrichment strategy with latent class analysis (LCA) may facilitate treatment strategies in subtypes of opioid misuse. We aim to identify subtypes of patients with opioid misuse and examine the distinctions between the subtypes by examining patient characteristics, topic models from clinical notes, and clinical outcomes.

Methods

This was an observational study of inpatient hospitalizations at a tertiary care center between 2007 and 2017. Patients with opioid misuse were identified using an operational definition applied to all inpatient encounters. LCA with eight class-defining variables from the electronic health record (EHR) was applied to

SUBMITTER: Afshar M 

PROVIDER: S-EPMC6634397 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature